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首页> 外文期刊>Hormone research >Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score.
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Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score.

机译:肾上腺皮质过早女孩的胰岛素抵抗预测模型。肾上腺皮质过早胰岛素抵抗评分:PAIR评分。

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摘要

AIM: The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche. METHODS: The insulin sensitivity index was calculated from the frequently sampled intravenous glucose tolerance test with tolbutamide. Thirty-five prepubertal girls (23 Caribbean-Hispanic and 12 African-American; mean age 6.8 years) were studied. The insulin sensitivity index was compared to birth weight, body mass index (BMI), the presence of acanthosis nigricans (AN), insulin-like growth factor 1, insulin-like growth factor binding protein 1, sex hormone binding globulin, lipid profile, and adrenocorticotropic hormone stimulated androgens. RESULTS: The best prediction models included birth weight, BMI, and AN (model 1: R(2) = 0.78) and BMI, AN, and serum 17-OH pregnenolone (model 2: R(2) = 0.76). When viewed as screening tests, a cutoff value <5.5 (premature adrenarche insulin resistance score) in both equations showed a sensitivity of 100% and a specificity of 85%. CONCLUSION: Born small for gestational age, premature adrenarche, obesity, AN, and higher serum 17-OH pregnenolone levels may confer negative, but independent, health risks.
机译:目的:本研究的目的是建立一个准确的回归模型,以预测肾上腺皮质过早女孩的胰岛素抵抗。方法:根据经常采样的甲苯磺丁脲进行的葡萄糖耐量试验,计算胰岛素敏感性指数。研究对象为35名青春期前女孩(23名加勒比海裔和12名非裔美国人;平均年龄6.8岁)。将胰岛素敏感性指数与出生体重,体重指数(BMI),黑棘皮病(AN),胰岛素样生长因子1,胰岛素样生长因子结合蛋白1,性激素结合球蛋白,脂质分布,和促肾上腺皮质激素刺激的雄激素。结果:最佳预测模型包括出生体重,BMI和AN(模型1:R(2)= 0.78)和BMI,AN和血清17-OH孕烯醇酮(模型2:R(2)= 0.76)。当作为筛查测试时,两个方程中的临界值均小于5.5(肾上腺皮质激素早期抵抗评分),其敏感性为100%,特异性为85%。结论:胎龄小,肾上腺皮质过早,肥胖,AN和血清17-OH孕烯醇酮水平较高可能给健康带来负面但独立的风险。

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