Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

摘要

Coordination of a cyclometallated Pt(ii) complex (1) to an amyloid-β peptide was probed by NMR and ESI-MS. Furthermore, EPR showed that binding of 1 to the Cu(ii)-amyloid-β species resulted in a reshuffling of the Cu(ii) coordination sphere, which was absent or lower for the sister non cyclometallated Pt(ii) complexes.