Statistical mechanical approach to competitive binding of metal ions to multi-center receptors

摘要

A microscopic site binding model to treat binding of several metal ions to multi-center receptors is proposed.The model introduces the appropriate parameterization in terms of microscopic complexation constants and metal-metal pair interaction energies.The model is solved with statistical mechanical techniques,including direct enumeration or transfer matrices.We obtain microscopic and macroscopic complexation constants,microstate probabilities,and binding isotherms for chain-like receptors,including the long-chain limit.Various examples to illustrate the usefulness of the model are given.