Cyclometallation of arylimines and nitrogen-containing heterocycles via room-temperature C-H bond activation with arene ruthenium(ii) acetate complexes

摘要

The reaction of [RuCl _2(p-cymene)] _2 with arylimines and 4 equiv. of KOAc in methanol at room temperature produces stable (N^C)-cyclometallated ruthenium(ii) complexes via C-H bond activation/ deprotonation. This method can be applied also to nitrogen-containing molecules: N-phenylpyrazole, 2-phenyl-2-oxazoline and benzo[h]quinoline. N-Phenyl-pyrazole, [RuCl _2(p-cymene)] _2 and diphenylacetylene directly lead to alkyne insertion into the metallacycle C-Ru bond.