Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.

Gunosewoyo H; Coster MJ; Bennett MR

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Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.

机译：Purinergic P2X（7）受体拮抗剂：化学筛选和生物筛选基础。

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The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.

机译：嘌呤能P2X（7）受体是ATP门控P2X家族的独特成员。该受体与多种疾病有关，并且已经通过高通量筛选发现了许多结构多样的配体。这种观点将试图突出生物学和化学领域的一些最新关键发现。

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《Bioorganic and medicinal chemistry》 |2009年第14期|共5页
作者
Gunosewoyo H; Coster MJ; Bennett MR;
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正文语种 eng
中图分类药学;生物化学;
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1. Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. [J] . Gunosewoyo H, Coster MJ, Bennett MR Bioorganic and medicinal chemistry . 2009,第14期

机译：Purinergic P2X（7）受体拮抗剂：化学筛选和生物筛选基础。
2. Development of structural models of purinergic P2X receptors and analysis of interaction with agonists and antagonists [J] . Dal Ben Diego, Buccioni Michela, Lambertucci Catia, Purinergic Signalling . 2014,第4期

机译：嘌呤能P2X受体结构模型的开发以及与激动剂和拮抗剂相互作用的分析
3. Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats. [J] . Niane LM, Donnelly DF, Joseph V, Journal of applied physiology . 2011,第1期

机译：通气和颈动脉体化学感受器对新生大鼠嘌呤能P2X受体拮抗剂的反应。
4. Molecular Dissection of Purinergic P2X Receptor Channels [C] . STANKO S. STOJILKOVIC, MELANIJA TOMI?, MU-LAN HE, International Biophysics Symposium . 2005

机译：嘌呤能P2X受体通道的分子解剖
5. New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors. [D] . Agnes, Richard Sario. 2003

机译：药物设计的新范例：设计和合成新型的生物活性肽，这些肽是阿片受体的激动剂，胆囊收缩素受体的拮抗剂。
6. Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats [O] . Lalah M. Niane, David F. Donnelly, Vincent Joseph, -1

机译：新生大鼠对嘌呤能P2X受体拮抗剂的通气和颈动脉体化学感受器反应
7. Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats [O] . Niane, Lalah M., Donnelly, David F., Joseph, Vincent, 2010

机译：新生大鼠对嘌呤能P2X受体拮抗剂的通气和颈动脉体化学感受器反应

Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.

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