Acute intussusception in infants and children as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation

摘要

To improve comparability of vaccine safety data, The Brighton Collaboration Intussusception Working Group has developed a case definition and guidelines for intussusception, applicable in study settings with different availability of resources, in health care settings that differ by availability of and access to health care, and in different geographic regions. This definition was developed on the basis of a report prepared for the Steering Committee on Diarrhoeal Disease Vaccines, Vaccine Development, World Health Organization (WHO), Geneva [1] and through group consensus of The Brighton Collaboration Intussusception Working Group. The WHO report is a comprehensive description of the incidence, clinical presentation, and management of acute intussusception in infants and children; it is based on a review of the published literature from 70 developing and developed countries. The phase 1 search of Medline and PubMed resulted in the identification of >3200 references published from 1966 through February 2001. The search was then limited to reflect the epidemiology and clinical presentation of intussusception in children ages 0-18 years. This search strategy resulted in the identification of 330 publications for review, of which 269 publications were selected and summarized in the WHO report.