Induction of resistance against Schistosoma mansoni infection by passive transfer of an IgG2a monoclonal antibody

摘要

An IgG2a monoclonal antibody (mAb) designated BRL4 mAb identified a 74-kDa antigen in antigenic extract of Schistosoma mansoni (Puerto Rican strain) adult worms. The target antigen was localized in gut and tegument. In 3 passive transfer experiments, the BRL4 mAb conferred 51.6, 41.9 and 53.8% protection levels in female Swiss mice. Histopathological examination revealed a marked decrease in number, size, collagen and reticular fibres of the liver granulomas. It is concluded that further experiments using purified 74-kDa-target antigen as a candidate vaccine will be performed.