Synthesis of functionalized acetophenones by formal [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-alkoxyand 3-silyloxy-2-acetyl-2-en-1-ones

摘要

The TiCl_4-mediated cyclization of 1,3-bis(silyloxy)-1,3- butadienes with 2-acetyl-1-silyloxybut-1-en-3-one and 3-acetyl-4-silyloxypent-3- en-2-one, readily available from 3-(formyl)acetylacetone and 3-(acetyl)acetylacetone (triacetylmethane), afforded a variety of functionalized acetophenones.