Direct cerebral and cardiac ~(17)O-MRI at 3 Tesla: initial results at natural abundance

摘要

Purpose To establish direct ~(17)O-magnetic resonance imaging (MRI) for metabolic imaging at a clinical field strength of 3 T. Methods An experimental setup including a surface coil and transmit/receive switch was constructed. Natural abundance in vivo brain images of a volunteer were acquired with a radial three-dimensional (3D) sequence in the visual cortex and in the heart with electrocardiogram (ECG)-gating. Results In the brain, a signal-to-noise ratio of 36 was found at a nominal resolution of (5.6 mm)~3, and a transverse relaxation time of T_2~* = (1.9 ± 0.2) ms was obtained. In the heart ~(17)O images were acquired with a temporal resolution of 200 ms. Conclusion Cerebral and cardiac ~(17)O-MRI at natural abundance is feasible at 3 T.