Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation

摘要

Object To determine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging could demonstrate signal recovery delay in irradiated areas of rat livers. We also investigated the relationship between MR imaging and histological findings. Materials and methods Twelve rats received 20 lmol iron/kg of SPIO followed by X-irradiation to the right upper abdomen 4 h later. Radiation doses were 0, 50 and 70 Gy. Hepatic signals were assessed on unenhanced T_2 * -weighted images for up to 7 days using a 9.4-Tesla scanner. The livers were excised on day 7 and examined histologically.