Measurement of anesthetic uptake kinetics in the brain using ~(19)F MRI and cross-correlation analysis after pulsed application

摘要

Object We present a pilot study based on ~(19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain. Method The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by ~(19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants. Results The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues. Conclusion The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.