Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4(+) T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface

Wang SongCun; Zhu XiaoYong; Xu YuanYuan; Zhang Di; Li YanHong; Tao Yu; Piao HaiLan; Li DaJin; Du MeiRong

首页> 外文期刊>Human Reproduction >Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4(+) T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface

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Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4(+) T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface

机译：程序性细胞死亡1（PD-1）和T细胞免疫球蛋白粘蛋白3（Tim-3）调节CD4（+）T细胞在母胎界面诱导2型辅助T细胞（Th2）偏倚。

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STUDY QUESTION: Are the immune regulatory molecules programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) involved in regulating CD4(+) T cell function during pregnancy?

机译：研究问题：免疫调节分子是否在怀孕期间调节细胞死亡1（PD-1）和T细胞免疫球蛋白粘蛋白3（Tim-3）参与调节CD4（+）T细胞功能？

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《Human Reproduction》 |2016年第4期|共12页
作者
Wang SongCun; Zhu XiaoYong; Xu YuanYuan; Zhang Di; Li YanHong; Tao Yu; Piao HaiLan; Li DaJin; Du MeiRong;
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正文语种 eng
中图分类人体生理学;
关键词
Tim-3; PD-1; CD4(+)T; trophoblast; Th2 bias; pregnancy; miscarriage;

机译：Tim-3;PD-1;CD4（+）T;滋养细胞;Th2偏倚;怀孕;流产;

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1. Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4(+) T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface [J] . Wang SongCun, Zhu XiaoYong, Xu YuanYuan, Human Reproduction . 2016,第4期

机译：程序性细胞死亡1（PD-1）和T细胞免疫球蛋白粘蛋白3（Tim-3）调节CD4（+）T细胞在母胎界面诱导2型辅助T细胞（Th2）偏倚。
2. Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface [J] . SongCun Wang, ChunMei Cao, HaiLan Piao, Scientific reports. . 2015,第1期

机译：Tim-3保护蜕膜基质细胞免受toll样受体介导的细胞凋亡和炎症反应，并促进母胎界面的Th2偏倚
3. Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma. [J] . Cetinozman F, Jansen PM, Willemze R American Journal of Surgical Pathology . 2012,第1期

机译：程序性死亡1在原发性皮肤CD4阳性小/中型多形T细胞淋巴瘤，皮肤假T细胞淋巴瘤和其他类型的皮肤T细胞淋巴瘤中的表达。
4. Mechanisms of Inhibition of Human Allergic Th2 Immune Responses by Regulatory T-Cells Induced by Interleukln 10-Treated Dendritic Cells and Transforming Growth Factor beta [C] . I. Bellinghausen, B. Konig, I. Bottcher, Collegium Internationale Allergologicum . 2007

机译：通过白细胞uck10-处理的树突细胞和转化生长因子β诱导的调节T细胞抑制人过敏Th2免疫应答的机制，转化生长因子β
5. Programmed cell death-1 ligation: A novel signal regulating development and apoptosis of retinal ganglion cells. [D] . Sham, Caroline Wingsy. 2010

机译：程序性细胞死亡1结扎：一种新型信号，调节视网膜神经节细胞的发育和凋亡。
6. Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface [O] . SongCun Wang, ChunMei Cao, HaiLan Piao, -1

机译：Tim-3保护蜕膜基质细胞免受toll样受体介导的细胞凋亡和炎症反应并促进母胎界面的Th2偏倚
7. Variable density of CD8+ and CD25+ programmed cell death-1 (PD-1) ligand (PD-L1) CD4+ T cells within the tumor microenvironment causes differential responses to the PD-1/PD-L1 blockade [O] . Si-Pei Wu, Yi-Long Wu 2015

机译：肿瘤微环境中CD8 +和CD25 +程序性细胞死亡1（PD-1）配体（PD-L1）CD4 + T细胞的可变密度导致对PD-1 / PD-L1阻断的不同反应

Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4(+) T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface

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