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Changes in the Temperament and Character Inventory dimensions after paroxetine treatment in patients with major depressive disorder

机译:重度抑郁症患者帕罗西汀治疗后气质和性格量表维度的变化

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Previous studies have reported changes in the dimensions of the Temperament and Character Inventory (TCI) after patients with major depressive disorder are treated. We aimed to investigate the changes in the TCI dimensions after paroxetine treatment in patients with major depressive disorder. Forty-eight patients were enrolled in this study and were treated with 10-40mg/day of paroxetine for 6weeks. The TCI was completed twice, at weeks 0 and 6. We used the Montgomery-Asberg Depression Rating Scale (MADRS) to evaluate patients. The participants were divided into three groups (responders, non-responders, and early responders) based on treatment response. The scores of each dimension of the TCI were compared before and after treatment using repeated-measures two-way analyses of variance. In the responders group (n=24), no TCI dimension scores changed significantly during treatment, but the interaction between sex and MADRS score change was significantly associated with the results. In the non-responders group (n=15), the self-directedness score increased significantly during the treatment period (p=0.000), and the change in MADRS score significantly affected the results. In the early responders group (n=9), no TCI dimension scores changed significantly during treatment. The results of the present study may reveal a possible correlation between paroxetine treatment and changes in personality traits. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译:先前的研究报道了重度抑郁症患者接受治疗后,气质和性格量表(TCI)尺寸的变化。我们旨在调查帕罗西汀治疗后重度抑郁症患者TCI维度的变化。这项研究纳入了48位患者,并接受10-40mg /天的帕罗西汀治疗6周。 TCI在第0周和第6周完成两次。我们使用蒙哥马利-阿斯伯格抑郁量表(MADRS)评估患者。根据治疗反应将参与者分为三类(反应者,非反应者和早期反应者)。使用重复测量双向方差分析比较治疗前后TCI各维度的得分。在应答者组(n = 24)中,TCI维度得分在治疗期间无明显变化,但性别与MADRS得分变化之间的相互作用与结果显着相关。在无反应者组(n = 15)中,自我指导得分在治疗期间显着增加(p = 0.000),并且MADRS得分的变化显着影响结果。在早期反应者组(n = 9)中,TCI维度得分在治疗期间无明显变化。本研究的结果可能表明帕罗西汀治疗与人格特质变化之间可能存在相关性。版权所有(c)2015 John Wiley&Sons,Ltd.

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