Production ofinflammatory cytokines in response to diphtheria-pertussis-tetanus (DPT), haemophilus influenzae type b (Hib), and 7-valent pneumococcal (PCV7) vaccines

摘要

A long-term vaccine gap occurred in Japan from 1993 when measles mumps and rubella combined vaccine (MMR) was discontinued because of the unexpectedly high incidence of aseptic meningitis caused by mumps vaccine components.1-2 Thereafter, new vaccines were not introduced until 2008. However, many pediatric vaccines have been approved with the implementation of recommended immunization schedules in developed countries, which shows that vaccine preventable diseases need to be controlled.