Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis

摘要

Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR]=1.158, 95% confidence interval [CI]=1.051-1.276, p=0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR=1.160, 95% CI=1.039-1.296, p=0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95% CI=1.030-1.619, p=0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223, 95% CI=0.981-1.526, p=0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR=1.402, 95% CI=1.001-1.964, p=0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR=1.656, 95% CI=1.087-2.523, p=0.019), but not in Asians (OR=1.100, 95% CI=0.703-1.721, p=0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95% CI=1.039-2.213, p=0.031) and Asians (OR=2.580, 95% CI=2.086-3.192, p1??10-9), but not in Europeans (OR=1.233, 95% CI=0.816-1.862, p=0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians. ? 2012 American Society for Histocompatibility and Immunogenetics.