Clozapine-lnduced Pulmonary Embolism: A Case Report and Literature Review

摘要

A 51-year-old white woman was admitted to the psychiatric ward of a hospital for depression. She had suicidal ideation, was experiencing ethanol abuse relapse, and had had auditory hallucinations caused by concomitant medication nonadherence for 2 weeks prior to admission. The patient smoked 2 packs of cigarettes per day and was adhering to a smoking cessation program that included the use of nicotine gum. She developed diffuse pulmonary emboli 15 days after clozapine initiation. Application of the Naranjo Adverse Drug Reaction Probability Scale to this case indicated a probable relationship between initial clozapine titration and the development of pulmonary emboli in the patient. Clozapine was discontinued without tapering, and the patient was discharged with prescriptions for fluphenazine and warfarin.