Liquid Oral Vaccine Mistakenly Given by Injection; Topical Anesthetics for Teething Infants

摘要

Liquid oral vaccine mistakenly given by injection. To protect children against rotavi-rus gastroenteritis, there are two oral live rotavirus vaccines available in the United States. These rotavirus vaccines are the only liquid oral vaccines given to children in the United States since use of live oral poliovirus vaccine was discontinued in 2000. Therefore, providers now have less experience administering oral vaccines and, on occasion, have accidentally injected oral rotavirus vaccine, making it ineffective. The Centers for Disease Control and Prevention (CDC) examined reports of accidental injection submitted to the Vaccine Adverse Event Reporting System (VAERS), operated jointly by CDC and the U.S. Food and Drug Administration (FDA) (Hibbs et al., 2014). There were 39 reports of accidental injection of the oral vaccine. ROTATEQ, a Merck product available as a liquid in a squeeze applicator (Figure 1), was involved in six of the errors. Most cases (33 out of 39) happened with the GlaxoSmithKline (GSK) product, ROTARIX, which requires recon-stitution.