Two new sesquiterpenes from the marine fungus Eutypella scoparia FS26 from the South China Sea

摘要

A new monocyclofarnesane-type sesquiterpene, 3,7,10-trihydroxy-6,11- cyclofarnes-1-ene (1), and a new acorane-type sesquiterpene, 8-(hydroxymethyl)-1-(2-hydroxy-1-methylethyl)-4-methylspiro[4.5]dec-8-en-7-ol (2), were isolated from the culture of Eutypella scoparia FS26 from the South China Sea, along with three known terpenes, 3-5. The structures of these compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1-5 were evaluated for their cytotoxic activities against the SF-268, MCF-7, and NCI-H460 tumor cell lines.