Lanostanoids Isolated from Ganoderma lucidum Mycelium Cultured by Submerged Fermentation

摘要

Three new lanostane triterpene acids, 3-O-acetylganoderic acid B (1), 8 beta,9 alpha-dihydroganoderic acid C (3), and 3-O-acetylganoderic acid K (4), as well as two new lanostane triterpene acid ethyl esters, ethyl 3-O-acetylganode rate B (2) and ethyl ganoderate J (5), were isolated and characterized from Ganoderma lucidum mycelia which was cultured by submerged fermentation method. Their structures were elucidated on the basis of spectroscopic methods. In addition, the identification of two known lanostane triterpene acid methyl esters, methyl O-acetyl ganoderate C and methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate were identified by comparison of the NMR data with those reported in the literature.