Bioactive Cytochalasins from Aspergillus flavipes, an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius

摘要

Five new cytochalasins, Z(16)-Z(20) (1-5), and three known ones, 6-8, were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z(17) (2) and rosellichalasin (8) showed cytotoxic activities against A-549 cell lines with IC50 values of 5.6 and 7.9 mu M, respectively.