New diterpene alkaloids from Aconitum sungpanense var. leucanthum

摘要

Five new C-19 diterpene alkaloids, leucanthurnsines A (1), B (2), C (3), D (4), and E (5), were isolated from the Chinese medicinal herb Aconitian sungpanense var. leucanthum, together with the known C-19 diterpene alkaloids pseudaconine, neoline, 1-O-methyldelphisine, crassicaudine, chasmanine, talatisamine, indaconitine, ezochansmanine, and leueantine D. The structures of these new alkaloids were elucidated by HR-MS and advanced NMR methods, including H-1- and C-13-NMR (DEPT), H-1,H-1-COSY, HMQC. and HMBC experiments.