A NOVEL ASYMMETRIC BENZOIN REACTION CATALYZED BY A CHIRAL TRIAZOLIUM SALT - PRELIMINARY COMMUNICATION

摘要

Using the chiral triazolium salt 1 as catalyst, a novel asymmetric variant of the benzoin reaction is reported. For the first time, the scope of the method is extended to a broader range of aromatic aldehydes 2, affording the acyloins 3a-h in yields of 22-72% and enantiomeric excesses up to 86%. [References: 26]