Improved Protocol for the Three-Component Biginelli Reactions and Biginelli-Like Mannich Reactions of Carbamates,Aldehydes,and Ketones

摘要

A mild,convenient,and improved method for the direct three-component Biginelli and Biginelli-like Mannich-type reactions of carbonyl compounds in the presence of inexpensive FeCl_3 o 6 H_2O and Me,SiCl as catalysts is described.Reactions performed with carbamates can be used to directly access N-protected beta-amino carbonyl compounds in a single step.