Synthesis of Novel Pyrazino[2,1-a]isoindolediones via Intramolecular Hydroamination of 2,3-Dihydro-3-oxo-2-(prop-2-yn-1-yl)-1H-isoindole-1-carboxamides

摘要

Novel derivatives of pyrazino[2,1-a]isoindolediones were synthesized through 6-exo-dig intramolecular hydroamination of 2,3-dihydro-3-oxo-2-(prop-2-yn-1-yl)-1H-isoindole-1-carboxamides followed by 1,3-H shift, in the presence of sodium hydride in DMF at 80 degrees. All products were obtained in good yields (60-80%) within short reaction time (40-60min).