A team from CSIRO Molecular & Health Technologies in Victoria,under the direction of Colin Ward,has determined the atomic structure of the insulin receptor (IR) ectodomain at a resolution of 3.8 A,showing two monomers arranged in a unique 'folded-over' conformation (McKern N.M,Lawrence M.C.,Streltsov VA.,Lou M.-Z,Adams T.E.,Lovrecz G.O,Elleman T.C.,Richards K.M.,BentleyJ.D.,Pilling P.A.,Hoyne PA.,Cartledge K.A.,Pham T.M.,Lewis J.L.,Sankovich S.E.,Stoichevska V,Da Silva E.,Robinson C.P.,Frenkel M.J.,Sparrow L.G.,Fernley R.T.,Epa VC,Ward C.W.,Nature,2006,443,218-21).
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