Pax-8 is a reliable marker in making the diagnosis in advanced stage epithelial ovarian carcinoma and primary peritoneal carcinoma for neoadjuvant chemotherapy on cell block and biopsy specimens

摘要

Sir. Primary tumour debulking (cytoreduction) followed by chemotherapy is considered the standard of care for patients with advanced stage epithelial ovarian cancer EOC/primary peritoneal carcinoma (PPC). As an alternative to this practice, neoadjuvant chemotherapy followed by cytoreduction surgery has been used where an accurate tissue diagnosis is usually required before the initiation of neoadjuvant chemotherapy.1 Immunohistochemistry (IRC) plays an important role in the evaluation of ovarian tumours especially in their advanced stage (stage IIIC and IV) where the major differential diagnosis could be malignant mesothelioma (MM) or adenocarcinoma from unknown origin.