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首页> 外文期刊>Heredity: An International Journal of Genetics >Spatio-temporal variation in the structure of a chromosomal polymorphism zone in the house mouse
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Spatio-temporal variation in the structure of a chromosomal polymorphism zone in the house mouse

机译:家鼠染色体多态性区结构的时空变化

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Several long-term temporal analyses of the structure of Robertsonian (Rb) hybrid zones in the western house mouse, Mus musculus domesticus, have been performed. Nevertheless, the detection of gradual or very rapid variations in a zone may be overlooked when the time elapsed between periods of study is too long. The Barcelona chromosomal polymorphism zone of the house mouse covers about 5000, km 2 around the city of Barcelona and is surrounded by 40 chromosome telocentric populations. Seven different metacentrics and mice with diploid numbers between 27 and 40 chromosomes and several fusions in heterozygous state (from one to seven) have been reported. We compare the present (period 2008-2010) and past (period 1996-2000) structure of this zone before examining its dynamics in more detail. Results indicate that there is not a Rb race in this area, which is consistent with the proposal that this zone was probably originated in situ, under a primary intergradation scenario. The lack of individuals with more than five metacentrics in heterozygous state in the current period suggests that selection acted against such mice. By contrast, this situation did not occur for mice with fewer than five fusions in heterozygous condition. Changes in human activity may affect the dynamics of gene flow between subpopulations, thus altering the chromosomal composition of certain sites. Although these local variations may have modified the clinal trend for certain metacentrics, the general staggered structure of the zone has not varied significantly in a decade.
机译:对西方家鼠小家鼠的罗伯逊(Rb)杂种区的结构进行了一些长期的时间分析。然而,当学习周期之间的时间过长时,可能会忽略区域中逐渐或非常迅速的变化的检测。家鼠的巴塞罗那染色体多态性区覆盖巴塞罗那市周围约5000 km 2,被40个染色体端粒种群包围。据报道,有七种不同的亚中心体和小鼠,其二倍体数在27至40条染色体之间,并且有几种杂合状态的融合体(从1到7条)。在更详细地检查其动态之前,我们将比较该区域的当前结构(2008-2010年)和过去结构(1996-2000年)。结果表明该地区没有Rb种族,这与该区域可能是原地过渡情况下可能原位起源的提议相一致。在当前时期缺乏杂合状态下具有超过五个亚中心的个体,这表明选择对此类小鼠起作用。相比之下,这种情况对于杂合条件下融合少于5次的小鼠不会发生。人类活动的变化可能会影响亚群之间基因流动的动态,从而改变某些位点的染色体组成。尽管这些局部变化可能已经改变了某些超中心点的渐进趋势,但该区域的总体交错结构在十年中并没有显着变化。

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