Noninvasive assessment of cystic fibrosis-associated liver disease with acoustic radiation force impulse imaging.

摘要

We read with great interest the article by Lewindon et al.1 The authors elegantly addressed the issue of hepatic disease in the natural history of patients with cystic fibrosis (cystic fibrosis-associated liver disease [CFLD]). Liver fibrosis, ranging from grade 1 to 4, was detected by dual-pass biopsy in most of the patients (77.5%).Incident portal hypertension (PHT) occurred in up to 42% of patients. Notably, clinical characterization did not predict the individual's risk of liver fibrosis or PHT, whereas dual-pass liver biopsy was informative of such risk.