Gamma heavy chain disease associated with large granular lymphocytic leukemia: A report of two cases and review of the literature

摘要

Objective and importance: Gamma heavy chain diseases (gamma HCD) and large granular lymphocyte (LGL) leukemia are two rare lymphoproliferative diseases, respectively with B and T phenotype. Both gamma HCD and LGL leukemia share some similar clinical features, such as cytopenias, splenomegaly, and recurrent infections. Association of these two diseases is exceptional and suggest pathogenic link. We report two cases of gamma HCD associated with T-LGL leukemia.