Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study

Kumada Hiromitsu; Hayashi Norio; Izumi Namiki; Okanoue Takeshi; Tsubouchi Hirohito; Yatsuhashi Hiroshi; Kato Mai; Rito Ki; Komada Yuji; Seto Chiharu; Goto Shoichiro

首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study

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Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study

机译：Simeprevir（TMC435）每天一次与聚乙二醇干扰素-α-2b和利巴韦林一起治疗基因型1型丙型肝炎病毒感染患者：CONCERTO-4研究

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AimThe efficacy and safety of simeprevir in combination with peginterferon--2b and ribavirin (PEG IFN--2b/RBV) were investigated in patients infected with hepatitis C virus (HCV) genotype 1 who were treatment-naive or had previously received interferon (IFN)-based therapy.

机译：目的研究西美普韦与聚乙二醇干扰素-2b和利巴韦林（PEG IFN--2b / RBV）联合使用对未接受过治疗或曾接受过干扰素（HCV）基因1型感染的丙型肝炎病毒患者的疗效和安全性。）为基础的疗法。

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《Hepatology research: the official journal of the Japan Society of Hepatology》 |2015年第5期|共13页
作者
Kumada Hiromitsu; Hayashi Norio; Izumi Namiki; Okanoue Takeshi; Tsubouchi Hirohito; Yatsuhashi Hiroshi; Kato Mai; Rito Ki; Komada Yuji; Seto Chiharu; Goto Shoichiro;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
chronic hepatitis C; direct-acting antiviral; protease inhibitor; simeprevir (TMC435); sustained virologic response;

机译：慢性丙型肝炎;直接作用抗病毒药;蛋白酶抑制剂;西美普韦（TMC435）;持续的病毒学应答;

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1. Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study [J] . Kumada Hiromitsu, Hayashi Norio, Izumi Namiki, Hepatology research: the official journal of the Japan Society of Hepatology . 2015,第5期

机译：Simeprevir（TMC435）每天一次与聚乙二醇干扰素-α-2b和利巴韦林一起治疗基因型1型丙型肝炎病毒感染患者：CONCERTO-4研究
2. Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-na?ve genotype 1 hepatitis C: The randomized PILLAR study [J] . FriedM.W., ButiM., DoreG.J., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2013,第6期

机译：每天一次的Simeprevir（TMC435）与聚乙二醇化干扰素和利巴韦林治疗初治型1型丙型肝炎：随机PILLAR研究
3. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: The COSMOS randomised study [J] . LawitzE., SulkowskiM.S., GhalibR., The Lancet . 2014,第9956期

机译：Simeprevir加sofosbuvir联合利巴韦林或不联合利巴韦林，用于治疗对聚乙二醇化干扰素和利巴韦林无反应的初治患者和初治患者的丙型肝炎病毒基因型1慢性感染：COSMOS随机研究
4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Once-daily simeprevir (TMC435) with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1-infected patients in Japan: the DRAGON study [O] . Norio Hayashi, Chiharu Seto, Mai Kato, -1

机译：DRAGON研究表明每天一次使用Simeprevir（TMC435）与聚乙二醇干扰素/利巴韦林治疗未感染过丙型肝炎的基因型1的患者
7. Once-daily simeprevir (TMC435) with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1-infected patients in Japan: the DRAGON study [O] . Norio Hayashi, Chiharu Seto, Mai Kato, 2013

机译：DRAGON研究表明，每天一次使用Simeprevir（TMC435）与聚乙二醇干扰素/利巴韦林治疗未感染过丙型肝炎的基因型1的患者

Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study

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