Brugada burden in Brugada syndrome: The way to go in risk stratification?

摘要

Better means for risk stratification of patients with asymptomatic Brugada syndrome are urgently needed.1 To begin with, the majority of Brugada syndrome patients encountered nowadays consistently belong to this category (63% of Brugada syndrome patients in Japan and 64% of those in Europe are asymptomatic when diagnosed). Moreover, in contrast to patients with long QT syndrome, who often have warning symptoms in the form of recurrent syncope before they develop cardiac arrest, arrhythmias in the Brugada syndrome often are lethal when they first occur. On the other hand, the absolute risk of developing spontaneous ventricular fibrillation (VF) among asymptomatic patients is lower than previously estimated.