A Randomized, Double-Blind, Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study)

Cady Roger K.; McAllister Peter J.; Spierings Egilius L. H.; Messina John; Carothers Jennifer; Djupesland Per G.; Mahmoud Ramy A.

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A Randomized, Double-Blind, Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study)

机译：舒马曲坦散剂（AVP-825）的呼吸动力鼻腔给药治疗急性偏头痛的随机，双盲，安慰剂对照研究（TARGET研究）

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ObjectiveTo evaluate the efficacy and safety of AVP-825, a drug-device combination of low-dose sumatriptan powder (22mg loaded dose) delivered intranasally through a targeted Breath Powered device vs an identical device containing lactose powder (placebo device) in the treatment of migraine headache.

机译：目的评估低剂量舒马曲坦粉剂（22mg负荷剂量）通过靶向呼吸动力设备与含乳糖粉的相同设备（安慰剂设备）经鼻腔给药的药物设备组合AVP-825的疗效和安全性偏头痛。

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来源
《Headache》 |2015年第1期|共13页
作者
Cady Roger K.; McAllister Peter J.; Spierings Egilius L. H.; Messina John; Carothers Jennifer; Djupesland Per G.; Mahmoud Ramy A.;
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正文语种 eng
中图分类诊断学;
关键词
migraine; Bi-Directional nasal delivery; Breath Powered nasal delivery; intranasal delivery; sumatriptan powder; AVP-825;

机译：偏头痛;双向鼻腔给药;呼吸动力鼻腔给药;鼻内给药;舒马曲坦粉;AVP-825;

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1. A Randomized, Double-Blind, Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study) [J] . Cady Roger K., McAllister Peter J., Spierings Egilius L. H., Headache . 2015,第1期

机译：舒马曲坦散剂（AVP-825）的呼吸动力鼻腔给药治疗急性偏头痛的随机，双盲，安慰剂对照研究（TARGET研究）
2. Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered((R)) Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan [J] . Silberstein Stephen, Winner Paul K., McAllister Peter J., Headache . 2017,第6期

机译：从随机罗盘研究的多次偏头痛攻击中的疗效和响应的效果和一致性的早期发病：AVP-825呼吸动力（（r））呼气输送系统（Sumatriptan鼻粉）与口腔舒适曲坦
3. Total Migraine Freedom for Breath Powered Intranasal Delivery of 22 Mg Sumatriptan Powder (AVP-825) versus 100 Mg Oral Sumatriptan from the COMPASS Study of Acute Treatment of Migraine [J] . Halker R., Tepper S. J., Siegert S., Headache . 2015,第S3期

机译：COMPASS研究急性偏头痛的COMPASS研究显示，通过呼吸动力经鼻腔内递送22 Mg苏门曲普坦散剂（AVP-825）与100 Mg口服苏门曲普坦的总偏头痛自由度
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. A Randomized Double-Blind Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study) [O] . Roger K Cady, Peter J McAllister, Egilius LH Spierings, -1

机译：舒马曲坦粉（AVP-825）的呼吸动力鼻腔给药治疗急性偏头痛的随机双盲安慰剂对照研究（TARGET研究）
7. PND7 Total Migraine freedom for breath powered intranasal delivery of 22 mg Sumatriptan Powder (Avp-825) Versus 100 mg oral sumatriptan from the compass study of acute treatment of Migraine [O] . Halker R., Tepper S., Siegert S., 2015

机译：PND7从偏头痛急性治疗的指南针研究中得出的22毫克舒马曲坦散剂（Avp-825）与100毫克口服舒马曲坦鼻腔给药的总偏头痛总呼吸自由度

A Randomized, Double-Blind, Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study)

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