Analysis of Gene Expression Profile in Lung Adenosquamous Carcinoma Using cDNA Microarray

摘要

Gene expression profile of the lung adenosqua-mous carcinoma was characterized by using cDNA microarray chip containing 4 096 human genes. Among target genes, 508 differentially expressed genes were identified in adenosqua-mous carcinoma of the lung,232 genes were overexpressed and 276 genes were under expressed. Among them, 92 genes are cell signals transduction genes, 34 genes are proto-onco-genes and tumor suppressor genes or cell cycle related genes or cell apoptosis related genes, 29 genes arecell skeleton genes, 28 genes are DNA synthesis, repair and recombination genes, 12 genes are DNA binding and transcription genes. These genes may be associated with the occurence and development of adenosquamous carinome of the lung.