Synthesis and Optical Resolution of 1-[(3-Carboxy-1,1 '-biphenyl)-2-yl]-1H-pyrrole-2-carboxylic Acid

摘要

Site selective mono- and dimetalation methods have been developed for the functionalization of 1-[(1,1'-biphenyl)-2-yl]-1H-pyrrole. Optical resolution of the prepared 1-[(3-carboxy-1,1'-biphenyl)-2-yl]pyrrole-2-carboxylic acid provided new atropisomeric 1-arylpyrrole derivatives. The absolute configuration of the pure dicarboxylic acid enantiomers was determined by single crystal X-ray diffraction and CD spectroscopy.