AIM: To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight. METHODS: Magnetic resonance spectroscopy and a previously validated gradient echo magnetic resonance imaging method with Dixon's two point technique were used in this study to quantify fat in liver, pancreas as well as kidney. RESULTS: In 36 volunteers with body mass index (BMI) ranging from 20.0 to 42.9 kg/m(2), the median fat content of liver, pancreas and kidney was 2.3% (interquartile range: 0.2%-7.8%), 2.7% (1.0%-6.5%) and 0.7% (0.1%-1.4%), respectively. BMI and subcutaneous fat correlated significantly with liver and pancreas fat content. We show for the first time the significant correlation of liver and pancreas fat content in healthy controls (r = 0.43, P < 0.01). These observations are related to body weight as measured by BMI and the amount of subcutaneous fat. Kidney fat content is very low and correlates with none of the other fat depots. CONCLUSION: Renal lipid accumulation, unlike the coupled accumulations of fat in liver and pancreas, is not observed in obese subjects. Unlike suggestions made in previous studies, renal lipid accumulation appears not to be involved in the pathogenesis of renal disease in humans.
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机译：目的：评估和关联肥胖受试者和正常体重者各个器官的脂质含量。方法：本研究使用磁共振波谱学和先前验证的梯度回波磁共振成像技术（用Dixon的两点技术）对肝脏，胰腺以及肾脏中的脂肪进行定量。结果：在36名体重指数（BMI）为20.0至42.9 kg / m（2）的志愿者中，肝脏，胰腺和肾脏的脂肪中位数为2.3％（四分位数范围为0.2％-7.8％），2.7％ （1.0％-6.5％）和0.7％（0.1％-1.4％）。 BMI和皮下脂肪与肝脏和胰腺脂肪含量显着相关。我们首次显示了健康对照组中肝脏和胰腺脂肪含量的显着相关性（r = 0.43，P <0.01）。这些观察结果与通过BMI测得的体重和皮下脂肪的含量有关。肾脏的脂肪含量很低，与其他脂肪库都没有关联。结论：与脂肪在肝脏和胰腺中的累积堆积不同，在肥胖受试者中未观察到肾脏脂质堆积。与以前的研究不同，肾脏脂质的蓄积似乎不参与人类肾脏疾病的发病机制。
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