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Selection of a TIPS stent for management of portal hypertension in liver cirrhosis: An evidence-based review

机译:选择TIPS支架治疗肝硬化门脉高压的循证研究

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摘要

Nowadays, transjugular intrahepatic portosystemic shunt (TIPS) has become a mainstay treatment option for the management of portal hypertension-related complications in liver cirrhosis. Accumulated evidence has shown that its indications are being gradually expanded. Notwithstanding, less attention has been paid for the selection of an appropriate stent during a TIPS procedure. Herein, we attempt to review the current evidence regarding the diameter, type, brand, and position of TIPS stents. Several following recommendations may be considered in the clinical practice: (1) a 10-mm stent may be more effective than an 8-mm stent for the management of portal hypertension, and may be superior to a 12-mm stent for the improvement of survival and shunt patency; (2) covered stents are superior to bare stents for reducing the development of shunt dysfunction; (3) if available, Viatorr stent-grafts may be recommended due to a higher rate of shunt patency; and (4) the placement of a TIPS stent in the left portal vein branch may be more reasonable for decreasing the development of hepatic encephalopathy. However, given relatively low quality of evidence, prospective well-designed studies should be warranted to further confirm these recommendations. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
机译:如今,经颈静脉肝内门体分流术(TIPS)已成为肝硬化门脉高压相关并发症管理的主要治疗选择。越来越多的证据表明,其适应症正在逐步扩大。尽管如此,在TIPS程序中选择合适的支架的关注却很少。本文中,我们试图回顾有关TIPS支架直径,类型,品牌和位置的当前证据。在临床实践中可以考虑以下几个建议:(1)10 mm支架在治疗门脉高压方面可能比8 mm支架更有效,并且在改善以下方面可能优于12 mm支架。生存和分流通畅; (2)覆膜支架优于裸支架,以减少分流功能障碍的发展; (3)如果有的话,由于较高的分流通畅率,可能建议使用Viatorr支架移植物; (4)将TIPS支架放置在左门静脉分支可能对于减少肝性脑病的发展更为合理。但是,鉴于证据质量相对较低,应保证进行精心设计的前瞻性研究以进一步证实这些建议。 (C)2014百事登出版集团有限公司。保留所有权利。

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