Oleic acid complex of bovine alpha-lactalbumin induces eryptosis in human and other erythrocytes by a Ca2+-independent mechanism

摘要

Background: Complexes of oleic acid (OA) with milk alpha-lactalbumin, received remarkable attention in view of their selective toxicity towards a spectrum of tumors during the last two decades. OA complexes of some structurally related/unrelated proteins are also tumoricidal. Erythrocytes are among the few differentiated cells that are sensitive and undergo hemolysis when exposed to the complexes.