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Vitiligo as an inflammatory skin disorder: A therapeutic perspective

机译:白癜风是一种炎症性皮肤病:一种治疗方法

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From a therapeutic standpoint, vitiligo is still regarded by many physicians as a simple problem of regenerative medicine, with the main aim to repopulate the depigmented skin with functional melanocytes from the margins of the lesions or from intact progenitors in hair follicles. However, recent research in vitiligo suggests that various local triggers alert the skin immune innate system and may precede adaptive immune responses targeting melanocytes. This scenario is close to that of other common skin inflammatory disorders like psoriasis and atopic, and suggests to target as a priority this clinically silent inflammatory component of he disease. This perspective highlights possible targets for intervention.
机译:从治疗的角度来看,白癜风仍被许多医生视为再生医学的简单问题,其主要目的是用来自病变边缘或毛囊完整祖细胞的功能性黑素细胞重新填充色素沉着的皮肤。但是,最近关于白癜风的研究表明,各种局部触发因素可警告皮肤免疫先天系统,并且可能先于针对黑素细胞的适应性免疫应答。这种情况与其他常见的皮肤炎性疾病(如牛皮癣和特应性疾病)相近,并建议将这种疾病的这种临床上无症状的炎症成分作为优先治疗对象。这种观点强调了可能的干预目标。

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