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首页> 外文期刊>Wiley Interdisciplinary Reviews. Membrane Transport and Signaling >The sugar phosphate/phosphate exchanger family SLC37
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The sugar phosphate/phosphate exchanger family SLC37

机译:磷酸糖/磷酸盐糖交换剂系列SLC37

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The solute-carrier (SLC) superfamily is divided into 55 different families of genes coding for integral membrane proteins, which transport not only all kinds of endogenous solute substrates, but also exogenous drugs and chemicals. The SLC37 transporters are members of the organophosphate:Pi antiporter family (OPA) and therefore they belong to the major facilitator superfamily (MFS). The SLC37 family members diverged early in evolution. SLC37A1 and SLC37A2 transporters are closely related and they have 57% of identical amino acids, while they have an average of 31% identical amino acids with SLC37A3. SLC37A4 is however quite different from them, sharing an average of 15% identity with the other three members. The SLC37A4 gene (also known as glucose-6-phosphate transporter, G6PT) is mutated in the glycogen storage disease non-1A type, therefore it is well studied both at the DNA and protein levels. Major function of SLC37A4 is to preserve interprandial glucose homeostasis. Data on SLC37A1 and SLC37A2genes expression are available both in humans and in mice, but there is still little information on their protein function. Even if they are homologous to glycerol-3-phosphate transporters, they were described to transport glucose-6-phosphate; therefore, they might be multisolute carriers. SLC37A3 is still poorly investigated and the only described feature is that it seems not to transport glucose-6-phosphate.
机译:溶质载体(SLC)超家族分为55个不同的编码完整膜蛋白的基因家族,它们不仅转运各种内源性溶质底物,还转运外源性药物和化学物质。 SLC37转运蛋白是有机磷酸盐:Pi反向转运蛋白家族(OPA)的成员,因此它们属于主要的促进子超家族(MFS)。 SLC37家族成员在进化初期分歧很大。 SLC37A1和SLC37A2转运蛋白密切相关,它们具有57%的相同氨基酸,而与SLC37A3平均具有31%的相同氨基酸。但是,SLC37A4与它们完全不同,与其他三个成员平均具有15%的同一性。 SLC37A4基因(也称为葡萄糖-6-磷酸转运蛋白,G6PT)在非1A型糖原贮积病中发生了突变,因此在DNA和蛋白质水平上都进行了深入研究。 SLC37A4的主要功能是保持餐间葡萄糖稳态。关于SLC37A1和SLC37A2基因表达的数据在人和小鼠中均可用,但是关于其蛋白功能的信息仍然很少。即使它们与3-磷酸甘油转运蛋白同源,也被描述为转运6-磷酸葡萄糖。因此,它们可能是多溶质载体。 SLC37A3仍未得到充分研究,唯一描述的特征是它似乎不运输6-磷酸葡萄糖。

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