A method to prepare a cobalt-carbon composite as a potential magnetic carrier for a drug delivery system

摘要

Magnetic drug delivery proposed in 1970 by Widder et al. [1] is a method to inject a magnetically susceptible material coated with a drug-laden matrix and then to use an externally placed magnet to guide the drug matrix to the target site. A composite of ferromagnetic material and activated carbon is generally used for such purpose. The ferromagnetic material such as iron provides the magnetic characteristic while activated carbon works as drug adsorption matrix. One of the methods [2] to prepare the magnetic target carrier (MTC) is by high impact ball milling process in which fine Fe particles are welded to activated carbon (AC) by utilizing the so called mechano-chemical effect. However, the major disadvantage is that it is easily separated into Fe and AC while being transferred in veins. In addition, the tissues are in direct contact with metal as Fe is not enclosed by the carbon matrix [3]. Konno et al. [4] prepared cobalt dispersed carbon sphere from chelate resin.