Diabetes mellitus: A risk factor for cancer and non-vascular disease deaths too

摘要

The Emerging Risk Factors Collaboration (ERFC) is an international collaboration established for conducting detailed re-analyses of worldwide data for molecules with sufficient data for potential exploration. ERFC has established a central database of over 1.2 million participants by collating more than 110 prospective population-based studies. After an initial focus on several lipid and inflammatory markers, in 2009, ERFC extended its scope to the association of diabetes and other metabolic markers with the risk of vascular disease and cause-specific death. In this study it attempted to determine reliable estimates of any independent associations of diabetes mellitus and fasting blood glucose level with the risk of death from cancer or other non-vascular conditions from 97 prospective studies. These studies (i) had complete information about age, sex, smoking status, body mass index (BMI), diagnosis of diabetes or fasting blood glucose level at baseline, (ii) did not select participants with previous chronic disease, (iii) recorded cause-specific mortality using well-defined criteria and (iv) accrued more than 1 year of follow up.