Effects of tiletamine/zolazepam or S(+) ketamine/midazolam/tramadol for chemical contention in red howler monkeys (Allouatta guariba clamitans)

摘要

Spolti P., De Moraes A.N., Tamanho R.B., Gehrcke M.I., Souza Junior J.C. & Oleskovicz N. 2013 [Effects of tiletamine/zolazepam or S(+) ketamine/midazolam/tramadol for chemical contention in red howler monkeys (Allouatta guariba clamitans).] Efeitos da associacao de tiletamina/zolazepam ou cetamina S(+)/midazolam/tramadol para contencao quimica em bugios-ruivos (Allouatta guariba clamitans). Pesquisa Veterinaria Brasileira 33(2):236-240. Departamento de Medicina Veterinaria, Centro de Ciencias Agroveterinarias, Universidade do Estado de Santa Catarina, Av. Luiz de Camoes 2090, Lages, SC 88520-000, Brazil. E-mail: a2no@cav.udesc.br Two protocols for chemical restraint in howler-redheads were evaluated. We used 12 healthy red howler monkeys, weighing 6.4 +/- 0.4 kg, which were fasted and without water six and two hours, respectively. The animals were divided into two groups that received intramuscular injection: TZ (n=6) which received tiletamine-zolazepam (Zoletil (R)) at a dose of 3.6mg/kg and CEMTRA (n=6) which received ketamine S (+), tramadol and midazolan (Cemtra (R), pilot batch 001/10, Ouro Fino Saude Animal Ltda, Cravinhos/SP, Brazil, comprising 100mg/ml of ketamine S (+), tramadol 20mg/ml and 10mg/ml of midazolam) in dose of 1ml of the association for each 10kg of body weight, equivalent doses of 10mg/kg, 1mg/kg and 2mg/kg, respectively. Prior to administration of drugs (M0) were evaluated: heart rate (HR), respiratory rate (RR), rectal temperature (RT), capillary refill time (CRT), systolic arterial pressure (SAP), hemoglobin oxygen saturation (SpO2), presence of salivation, degree of muscle relaxation and sedation, Bispectral index (BIS) and Signal Quality BIS (SQI), interdigital pinch response and latency times, ambulation and total recovery (TRT). The parameters were reassessed M5, M10, M20, M30, M40 and M50 (5, 10, 20, 30, 40 and 50 minutes after drug administration). In TZ animals were more responsive to the interdigital pinch over time. The animals of CEMTRA showed a higher degree of muscle relaxation and sedation. The RR of CEMTRA was lower after administration of treatment at all times in relation to M0. Among the groups RR of CEMTRA was lower compared to the TZ in M2 and M4. The total time of sedation and recovery was 48 +/- 4 min and 150.1 +/- 42.1 for the CEMTRA and 38 +/- 7 and 73.1 +/- 20.6 for the TZ. We conclude that both formulations are safe for containing chemical howler, and the CEMTRA showed better sedation and muscle relaxant.