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首页> 外文期刊>Virchows Archiv: an international journal of pathology >Detection of USP6 gene rearrangement in nodular fasciitis: An important diagnostic tool
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Detection of USP6 gene rearrangement in nodular fasciitis: An important diagnostic tool

机译:结节性筋膜炎中USP6基因重排的检测:重要的诊断工具

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Nodular fasciitis is a lesion that is well known for posing a diagnostic challenge to pathologists. The clinical presentation of sudden onset and fast growing rate of this soft tissue lesion along with histological features, comprising a poorly demarcated cellular myofibroblastic mitotically active lesion, frequently raises concern of malignancy.There are no specific immunohistochemical markers for nodular fasciitis and the diagnosis, until recently, was based on histological features alone. The age of occurrence and anatomical site are unhelpful in making the diagnosis as these lesions can occur at any age and at any anatomic soft tissue site, although the most frequent site is the forearm and the trunk and is more common in young adults [5]. These lesions have traditionally been considered reactive in nature because if unresected, they may involute and are not associated with malignant transformation. If the patient is quizzed, a history of trauma to the site of tumour may be obtained.
机译:结节性筋膜炎是一种病因,向病理学家提出诊断挑战。这种软组织病变的突然发作和快速增长的临床表现以及组织学特征(包括界限分明的细胞性肌纤维母细胞有丝分裂活动性病变)经常引起恶性肿瘤的关注,对于结节性筋膜炎和诊断尚无特异性的免疫组织化学标记物,直到最近,仅基于组织学特征。发生的年龄和解剖部位无助于诊断,因为这些病变可发生在任何年龄和任何解剖软组织部位,尽管最常见的部位是前臂和躯干,并且在年轻人中更为常见[5] 。传统上认为这些病变本质上是反应性的,因为如果不切除,它们可能会渐开线并且与恶性转化无关。如果对患者进行检查,则可能会获得肿瘤部位的创伤史。

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