Comparative efficacy of diclazuril (Vecoxan (R)) and toltrazuril (Baycox bovis (R)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves

摘要

A blinded, randomized, controlled, multi-centric field study was conducted on French dairy farms (n = 9) to evaluate the long term efficacy of metaphylactic, single oral treatments with either 1 mg/kg body weight (BW) of diclazuril (Vecoxan (R)), or 15 mg/kg BW of toltrazuril (Baycox (R)) against natural infections with Eimeria zuemii and/or Eimeria bovis, compared to untreated control animals. A total of 199 calves from nine commercial farms aged between 21 and 55 days old at the start of study were included and randomly allocated to one of three groups. Calves on all farms were observed for a period of 78 days post treatment, using both parasitological (oocyst excretion), and clinical parameters (faecal score and body weight). The assessment of efficacy was based on both control of oocyst excretion, and on the average daily weight gains throughout the study.