A novel domino-click approach for the synthesis of sugar based unsymmetrical bis-1,2,3-triazoles

摘要

Aryl or sugar azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted-butynyl-N-aryl or N-glycosyl-1,2,3-bistriazoles in a domino fashion. Upon Cu(I) catalyzed 1,3-dipolar cycloaddition with sugar azides, these compounds afford novel unsymmetrical bis-1,2,3-triazoles in high yields. (c) 2007 Elsevier Ltd. All rights reserved.