SYNTHESIS OF NOVEL VITAMIN C PHOSPHODIESTERS - STABILITY AND ANTIOXIDANT ACTIVITY

摘要

A novel series of hybrid L-ascorbic acid (vitamin C) phophodiesters linked at the C-2 hydroxyl group with other biologically active substances, namely myo-inositol, arbutin, 4-hydroxy-L-proline. and glycolic acid were synthesized, and their thermal stability and reducing activity against free radicals were estimated in vitro. All of the phosphodiesters exhibited high thermal stabilities: however, their antioxidant activities in vitro were generally lower than that of vitamin C. (C) 1996 Elsevier Science Ltd. [References: 57]