首页> 外文期刊>Vascular pharmacology >Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats (Reprinted from Vascular Pharmacology, 61, pg 16-24)
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Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats (Reprinted from Vascular Pharmacology, 61, pg 16-24)

机译:血红素加氧酶-1的诱导可改善链脲佐菌素诱导的2型糖尿病大鼠的血管功能障碍(转载自Vascular Pharmacology,61,第16-24页)

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摘要

Aims: To explore the effects of heme oxygenase-1 (HO-1) on vascular dysfunction in high fat diet streptozotocin-induced type 2 diabetic (T2D) rats. Methods: Rats received a high-fat diet followed by a low dose of streptozotocin (30 mg/kg) to induce T2D. T2D rats were treated with hemin (1, 5, or 25 mg/kg) or carbon monoxide-releasing molecule-2 (CORM-2, 5 mg/kg) for 4 weeks. Isometric contractions of aortic rings were measured. The expression of cyclooxygenase-2 (COX-2) and activities of HO, SOD, and MDA were evaluated.
机译:目的:探讨血红素加氧酶-1(HO-1)对高脂饮食链脲佐菌素诱发的2型糖尿病(T2D)大鼠血管功能障碍的影响。方法:大鼠接受高脂饮食,然后低剂量链脲佐菌素(30 mg / kg)诱导T2D。 T2D大鼠用血红素(1、5、25毫克/千克)或一氧化碳释放分子2(CORM-2、5毫克/千克)治疗4周。测量主动脉环的等距收缩。评估环氧合酶2(COX-2)的表达以及HO,SOD和MDA的活性。

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