Lingual antimicrobial peptide (LAP) belongs to the beta-defensin family in cattle and is found in milk. LAP concentrations increase in milk from mastitic udders; however, the relationship between LAP concentrations and the somatic cell count (SCC) in milk remains to be elucidated in detail. Therefore, the present study was undertaken to investigate the relationship between LAP concentrations and the SCC in bovine milk to assess whether LAP may be used as an indicator of SCC. Milk was collected from 66 udders showing various SCCs. The SCC and LAP concentrations were measured in the milk. A significantly higher LAP concentration was observed in milk having 500-5000 x 10(3) cells/ml and >5000 x 10(3) cells/ml SCC groups than in lower SCC groups (<50 x 10(3) cells/ml and 50-500 x 10(3) cells/ml). A significantly positive correlation between LAP concentrations and SCCs in milk was observed (r = 0.68). In milk samples with >26 nM of LAP, 92.0% of milk samples had high SCCs (>200 x 10(3) cells/ml). The concentration of LAP in milk infected with Staphylococcus aureus, Streptococcus bovis, Streptococcus dysgalactiae, and Escherichia coli was significantly higher than that in uninfected milk. These results suggest that the concentration of LAP can be a useful indicator of the SCC in dairy cows
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机译：舌头抗菌肽（LAP）属于牛的β-防御素家族，存在于牛奶中。乳腺中乳汁中的LAP浓度增加;然而，牛奶中LAP浓度与体细胞计数（SCC）之间的关系仍有待详细阐明。因此，本研究旨在调查牛乳中LAP浓度与SCC之间的关系，以评估LAP是否可以用作SCC的指标。从66个显示不同SCC的乳房中收集牛奶。测量牛奶中的SCC和LAP浓度。在SCC组中具有500-5000 x 10（3）个细胞/ ml和> 5000 x 10（3）个细胞/ ml的牛奶中，观察到的LAP浓度显着高于较低的SCC组（<50 x 10（3）个细胞/ ml）和50-500 x 10（3）个细胞/毫升）。观察到牛奶中LAP浓度与SCC之间呈显着正相关（r = 0.68）。在LAP大于26 nM的牛奶样品中，有92.0％的牛奶样品具有较高的SCC（> 200 x 10（3）细胞/ ml）。感染金黄色葡萄球菌，牛链球菌，dysgalactiae链球菌和大肠杆菌的牛奶中的LAP浓度显着高于未感染的牛奶。这些结果表明，LAP的浓度可以作为奶牛SCC的有用指标。
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