Crystal structure of a hydrated N-glycoprotein linkage region model and its analogue: Hydrogen bonding and pi-pi stacking driven molecular assembly

摘要

X-Ray diffraction analysis of a hydrated N-glycoprotein linkage region model, N-1-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)acetamide (1) and its N-1-benzamido analogue 2 reveals very interesting molecular architecture involving seven hydrogen bonds in both compounds and further stabilization of packing in 2 due to pi-pi stacking. The crystal structure has a two dimensional network of hydrogen bonds formed by infinite chains running along the b-axis and homodromic cycles, intersecting at the water oxygens. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 16]