THE CHEMICAL SYNTHESIS OF LEISHMANIA DONOVANI PHOSPHOGLYCAN VIA POLYCONDENSATION OF A GLYCOBIOSYL HYDROGENPHOSPHONATE MONOMER

摘要

A polycondensation of 2,3,6-tri-O-benzoyl-4-O-(2,3,4-tri-O-benzoyl-beta-D-galactopyranosyl)-alph a-D-mannopyranosyl hydrogenphosphonate in the presence of trimethylacetyl chloride has been used to synthesize a linear poly[ beta-D-galactopyranosyl-(1-,4)-alpha-D-mannopyranosyl phosphate] representing the phosphoglycan part of the lipophosphoglycan from Leishmania donovani. [References: 8]